Blar i forfatter "Berdal, Margrete"

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    • Effects of AGE inhibition with aminoguanidine in a diabetic db/db mouse wound model 

      Berdal, Margrete; Jenssen, Trond Geir (Journal article; Tidsskriftartikkel; Peer reviewed, 2014)
      Advanced glycation end products (AGEs) react non-enzymatically with tissue proteins to form irreversible structures involved in atherosclerosis, nephropathy, retinopathy, neuropathy, and wound healing. Studies on AGE-inhibitors have demonstrated possible prevention of diabetes complications. The present open label study was conducted on aminoguanidine (AGu), an inhibitor of AGE-formation, to ...

    • No association between glycemia and wound healing in an experimental db/db mouse model 

      Berdal, Margrete; Jenssen, Trond (Journal article; Tidsskriftartikkel; Peer reviewed, 2013)
      Impaired wound healing is a frequent problem in diabetes. Hyperglycemia may be an operative mechanism, but a link between glycemic control and wound healing has never been established.Wounds in db/db mice have been extensively studied. This study was undertaken to see if plasma glucose was a predictor of wound healing. An excisional wound was made (149 db/db mice). Wound closure was studied versus ...

    • Wound healing in diabetes. An intervention study in db/db mice 

      Berdal, Margrete (Doctoral thesis; Doktorgradsavhandling, 2017-06-09)
      The prevalence of diabetes is increasing globally. Certain microvascular and macrovascular complications such as cardiovascular disease, retinopathy, nephropathy, neuropathy, and impaired wound healing are associated with the disease. Prolonged exposure to hyperglycaemia plays an important role in their development. Glucose reacts with macromolecules including proteins, lipoproteins, and nucleic ...